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Engineering Next-Generation T Cells for Cancer Immunotherapy

Thursday, December 7, 2017
4:00 PM - 5:00 PM
Location: Spalding Laboratory 106 (Hartley Memorial Seminar Room)
Yvonne Chen, Assistant Professor, Department of Chemical and Biomolecular Engineering, University of California, Los Angeles

The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has demonstrated clinical efficacy in the treatment of advanced cancers, with anti-CD19 CAR-T cells achieving up to 90% complete remission among patients with relapsed B-cell malignancies. However, challenges such as antigen escape and immunosuppression limit the long-term efficacy of adoptive T-cell therapy. Here, I will discuss the development of next-generation T cells that can target multiple cancer antigens and resist immunosuppression, thereby increasing the robustness of therapeutic T cells against tumor defense mechanisms. This presentation will highlight the the potential of synthetic biology in generating novel mammalian cell system with multifunctional outputs for therapeutic applications.

Series: Chemical Engineering Seminar
For more information, please phone (626) 395-4115 or email allison@cheme.caltech.edu

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